HLA-Cw*04 allele associated with nevirapine-induced rash in HIV-infected Thai patients.

ABSTRACT:

Background

A high incidence of rash has been reported in HIV-1 patients who received the anti-retroviral drug nevirapine. In addition, several studies have suggested that polymorphisms of human leukocyte antigen (HLA) genes may play important roles in nevirapine-induced rash. The aim of the present study was to evaluate the effects of different HLA-C alleles on rash associated with nevirapine in patients who started highly active anti-retroviral therapy (HAART) containing nevirapine in Thailand.

Results

A case-control study was carried out involving HIV-1 patients under treatment at Bamrasnaradura Infectious Diseases Institute, Nonthaburi, Thailand between March 2007 and March 2008. The study included all HIV/AIDS patients being treated with nevirapine-containing regimens. T

SUBMITTER: Likanonsakul S 

PROVIDER: S-EPMC2774340 | biostudies-literature | 2009 Oct

REPOSITORIES: biostudies-literature