A structure filter for the Eukaryotic Linear Motif Resource.

ABSTRACT:

Background

Many proteins are highly modular, being assembled from globular domains and segments of natively disordered polypeptides. Linear motifs, short sequence modules functioning independently of protein tertiary structure, are most abundant in natively disordered polypeptides but are also found in accessible parts of globular domains, such as exposed loops. The prediction of novel occurrences of known linear motifs attempts the difficult task of distinguishing functional matches from stochastically occurring non-functional matches. Although functionality can only be confirmed experimentally, confidence in a putative motif is increased if a motif exhibits attributes associated with functional instances such as occurrence in the correct taxonomic range, cellular compartment, con

SUBMITTER: Via A 

PROVIDER: S-EPMC2774702 | biostudies-literature | 2009 Oct

REPOSITORIES: biostudies-literature