Matrix protein 2 of influenza A virus blocks autophagosome fusion with lysosomes.

ABSTRACT: Influenza A virus is an important human pathogen causing significant morbidity and mortality every year and threatening the human population with epidemics and pandemics. Therefore, it is important to understand the biology of this virus to develop strategies to control its pathogenicity. Here, we demonstrate that influenza A virus inhibits macroautophagy, a cellular process known to be manipulated by diverse pathogens. Influenza A virus infection causes accumulation of autophagosomes by blocking their fusion with lysosomes, and one viral protein, matrix protein 2, is necessary and sufficient for this inhibition of autophagosome degradation. Macroautophagy inhibition by matrix protein 2 compromises survival of influenza virus-infected cells but does not influence viral replication. We prop

SUBMITTER: Gannage M 

PROVIDER: S-EPMC2774833 | biostudies-literature | 2009 Oct

REPOSITORIES: biostudies-literature