Cyclophilin A mediates vascular remodeling by promoting inflammation and vascular smooth muscle cell proliferation.

ABSTRACT:

Background

Oxidative stress, generated by excessive reactive oxygen species, promotes cardiovascular disease. Cyclophilin A (CyPA) is a 20-kDa chaperone protein secreted from vascular smooth muscle cells (VSMCs) in response to reactive oxygen species that stimulates VSMC proliferation and inflammatory cell migration in vitro; however, the role CyPA plays in vascular function in vivo remains unknown.

Methods and results

We tested the hypothesis that CyPA contributes to vascular remodeling by analyzing the response to complete carotid ligation in CyPA knockout mice, wild-type mice, and mice that overexpress CyPA in VSMC (VSMC-Tg). After carotid ligation, CyPA expression in vessels of wild-type mice increased dramatically and was significantly greater in VSMC-Tg mice. Reactive

SUBMITTER: Satoh K 

PROVIDER: S-EPMC2775430 | biostudies-literature | 2008 Jun

REPOSITORIES: biostudies-literature