Allele-specific DNA methylation in mouse strains is mainly determined by cis-acting sequences.

ABSTRACT: DNA methylation is a vital epigenetic mark that participates in establishing and maintaining chromatin structures and regulates gene transcription during mammalian development and cellular differentiation. Differences in epigenetic patterns between individuals may contribute to phenotypic variation and disease susceptibility; however, little is known about the extent of such variation or how different epigenetic patterns are established. Here we have compared DNA methylation profiles of macrophages from two inbred mouse strains (C57BL/6 and BALB/c) at 181 large genomic intervals that were selected based on differential gene expression patterns. Using a DNA methylation-dependent fractionation approach based on a combination of methyl-CpG immunoprecipitation and locus-wide tiling arrays, we

SUBMITTER: Schilling E 

PROVIDER: S-EPMC2775599 | biostudies-literature | 2009 Nov

REPOSITORIES: biostudies-literature