Genetic variation and recent positive selection in worldwide human populations: evidence from nearly 1 million SNPs.

ABSTRACT:

Background

Genome-wide scans of hundreds of thousands of single-nucleotide polymorphisms (SNPs) have resulted in the identification of new susceptibility variants to common diseases and are providing new insights into the genetic structure and relationships of human populations. Moreover, genome-wide data can be used to search for signals of recent positive selection, thereby providing new insights into the genetic adaptations that occurred as modern humans spread out of Africa and around the world.

Methodology

We genotyped approximately 500,000 SNPs in 255 individuals (5 individuals from each of 51 worldwide populations) from the Human Genome Diversity Panel (HGDP-CEPH). When merged with non-overlapping SNPs typed previously in 250 of these same individuals, the resulting d

SUBMITTER: Lopez Herraez D 

PROVIDER: S-EPMC2775638 | biostudies-literature | 2009 Nov

REPOSITORIES: biostudies-literature