The association of endogenous sex hormones, adiposity, and insulin resistance with incident diabetes in postmenopausal women.

ABSTRACT:

Context

In postmenopausal women, endogenous bioavailable testosterone (T) and estradiol (E2) have been positively associated, and SHBG has been negatively associated, with incident type 2 diabetes (T2DM). Previous studies have not explored possible factors explaining these relationships.

Objective

Our objective was to examine the association of endogenous sex hormones with incident T2DM in postmenopausal women and possible explanatory factors.

Design, setting, and participants

The Multi-Ethnic Study of Atherosclerosis (MESA) is a prospective study that included 1612 postmenopausal women aged 45-84 yr, followed between the years 2000-2006, who were not taking hormone replacement therapy, had no prevalent cardiovascular disease or diabetes, and had complete ascertainmen

SUBMITTER: Kalyani RR 

PROVIDER: S-EPMC2775652 | biostudies-literature | 2009 Nov

REPOSITORIES: biostudies-literature