The impact of exercise training compared to caloric restriction on hepatic and peripheral insulin resistance in obesity.

ABSTRACT:

Context

It has been difficult to distinguish the independent effects of caloric restriction versus exercise training on insulin resistance.

Objective

Utilizing metabolic feeding and supervised exercise training, we examined the influence of caloric restriction vs. exercise training with and without weight loss on hepatic and peripheral insulin resistance.

Design, participants, and intervention

Thirty-four obese, older subjects were randomized to: caloric restriction with weight loss (CR), exercise training with weight loss (EWL), exercise training without weight loss (EX), or controls. Based on an equivalent caloric deficit in EWL and CR, we induced matched weight loss. Subjects in the EX group received caloric compensation. Combined with [6,6(2)H(2)]glucose, an octre

SUBMITTER: Coker RH 

PROVIDER: S-EPMC2775654 | biostudies-literature | 2009 Nov

REPOSITORIES: biostudies-literature