A haplotype containing quantitative trait loci for SLC1A1 gene expression and its association with obsessive-compulsive disorder.

ABSTRACT:

Context

Recent evidence from linkage analyses and follow-up candidate gene studies supports the involvement of SLC1A1, which encodes the neuronal glutamate transporter, in the development of obsessive-compulsive disorder (OCD).

Objectives

To determine the role of genetic variation of SLC1A1 in OCD in a large case-control study and to better understand how SLC1A1 variation affects functionality.

Design

A case-control study.

Setting

Publicly accessible SLC1A1 expression and genotype data.

Patients

Three hundred twenty-five OCD probands and 662 ethnically and sex-matched controls.

Interventions

Probands were assessed with the Structured Clinical Interview for DSM-IV, the Yale-Brown Obsessive Compulsive Scale, and the Saving Inventory-Revised. Six sin

SUBMITTER: Wendland JR 

PROVIDER: S-EPMC2775716 | biostudies-literature | 2009 Apr

REPOSITORIES: biostudies-literature