Developing a set of ancestry-sensitive DNA markers reflecting continental origins of humans.

ABSTRACT:

Background

The identification and use of Ancestry-Sensitive Markers (ASMs), i.e. genetic polymorphisms facilitating the genetic reconstruction of geographical origins of individuals, is far from straightforward.

Results

Here we describe the ascertainment and application of five different sets of 47 single nucleotide polymorphisms (SNPs) allowing the inference of major human groups of different continental origin. For this, we first used 74 cell lines, representing human males from six different geographical areas and screened them with the Affymetrix Mapping 10K assay. In addition to using summary statistics estimating the genetic diversity among multiple groups of individuals defined by geography or language, we also used the program STRUCTURE to detect genetically distinct

SUBMITTER: Kersbergen P 

PROVIDER: S-EPMC2775748 | biostudies-literature | 2009 Oct

REPOSITORIES: biostudies-literature