Ontology highlight
ABSTRACT:
SUBMITTER: Renault VM
PROVIDER: S-EPMC2775802 | biostudies-literature | 2009 Nov
REPOSITORIES: biostudies-literature
Cell stem cell 20091101 5
In the nervous system, neural stem cells (NSCs) are necessary for the generation of new neurons and for cognitive function. Here we show that FoxO3, a member of a transcription factor family known to extend lifespan in invertebrates, regulates the NSC pool. We find that adult FoxO3(-/-) mice have fewer NSCs in vivo than wild-type counterparts. NSCs isolated from adult FoxO3(-/-) mice have decreased self-renewal and an impaired ability to generate different neural lineages. Identification of the ...[more]