Influence of membrane CD25 stability on T lymphocyte activity: implications for immunoregulation.

ABSTRACT:

Background

CD25, a component of the IL-2 receptor, is important in T cell proliferation, activation induced cell death, as well as the actions of both regulatory (Treg) and effector (Teff) T cells. Recent genome wide association studies have implicated the CD25 locus as an important region for genetic susceptibility to a number of autoimmune disorders, with serum levels of soluble CD25 receptor (sCD25) serving as a potential phenotypic marker for this association. However, the functional impact of CD25 cleavage, as well as the influence of sCD25 on immunoregulatory activities, remain largely unknown and form the basis of this effort.

Methodology/principal findings

The generation of sCD25 by Treg (CD4(+)CD25(+)) and Teff (CD4(+)CD25(-)) cells was examined during in vitro supp

SUBMITTER: Brusko TM 

PROVIDER: S-EPMC2775921 | biostudies-literature | 2009 Nov

REPOSITORIES: biostudies-literature