Shared and idiosyncratic cortical activation patterns in autism revealed under continuous real-life viewing conditions.

ABSTRACT: Although widespread alterations in cortical structure have been documented in individuals with autism, the functional implications of these alterations remain to be determined. Here, we adopted a novel inter-subject correlation (inter-SC) and intra-subject correlation (intra-SC) technique to quantify the reliability of the spatio-temporal responses of functional MR activity in adults with autism during free-viewing of a popular audio-visual movie. Whereas these complex stimuli evoke highly reliable shared response time courses in typical individuals, cortical activity was more variable across individuals with autism (low inter-SC). Interestingly, when we measured the responses within an autistic individual across repeated presentations of the movie, we observed a unique, idiosyncratic resp

SUBMITTER: Hasson U 

PROVIDER: S-EPMC2775929 | biostudies-literature | 2009 Aug

REPOSITORIES: biostudies-literature