Gene expression profiling during early acute febrile stage of dengue infection can predict the disease outcome.

ABSTRACT:

Background

We report the detailed development of biomarkers to predict the clinical outcome under dengue infection. Transcriptional signatures from purified peripheral blood mononuclear cells were derived from whole-genome gene-expression microarray data, validated by quantitative PCR and tested in independent samples.

Methodology/principal findings

The study was performed on patients of a well-characterized dengue cohort from Recife, Brazil. The samples analyzed were collected prospectively from acute febrile dengue patients who evolved with different degrees of disease severity: classic dengue fever or dengue hemorrhagic fever (DHF) samples were compared with similar samples from other non-dengue febrile illnesses. The DHF samples were collected 2-3 days before the present

SUBMITTER: Nascimento EJ 

PROVIDER: S-EPMC2775946 | biostudies-literature | 2009 Nov

REPOSITORIES: biostudies-literature