Early-onset and robust amyloid pathology in a new homozygous mouse model of Alzheimer's disease.

ABSTRACT:

Background

Transgenic mice expressing mutated amyloid precursor protein (APP) and presenilin (PS)-1 or -2 have been successfully used to model cerebral beta-amyloidosis, one of the characteristic hallmarks of Alzheimer's disease (AD) pathology. However, the use of many transgenic lines is limited by premature death, low breeding efficiencies and late onset and high inter-animal variability of the pathology, creating a need for improved animal models. Here we describe the detailed characterization of a new homozygous double-transgenic mouse line that addresses most of these issues.

Methodology/principal findings

The transgenic mouse line (ARTE10) was generated by co-integration of two transgenes carrying the K670N/M671L mutated amyloid precursor protein (APP(swe)) and the M14

SUBMITTER: Willuweit A 

PROVIDER: S-EPMC2775952 | biostudies-literature | 2009 Nov

REPOSITORIES: biostudies-literature