P38gamma mitogen-activated protein kinase is a key regulator in skeletal muscle metabolic adaptation in mice.

ABSTRACT: Regular endurance exercise induces skeletal muscle contractile and metabolic adaptations, conferring salutary health benefits, such as protection against the metabolic syndrome. The plasticity of skeletal muscle has been extensively investigated, but how the adaptive processes are precisely controlled is largely unknown. Using muscle-specific gene deletion in mice, we now show that p38gamma mitogen-activated protein kinase (MAPK), but not p38alpha and p38beta, is required for endurance exercise-induced mitochondrial biogenesis and angiogenesis, whereas none of the p38 isoforms are required for IIb-to-IIa fiber-type transformation. These phenotypic findings were further supported by microarray and real-time PCR analyses revealing contractile activity-dependent p38gamma target genes, includi

SUBMITTER: Pogozelski AR 

PROVIDER: S-EPMC2775956 | biostudies-literature | 2009 Nov

REPOSITORIES: biostudies-literature