Copper-mediated amidation of heterocyclic and aromatic C-H bonds.

ABSTRACT: A copper-mediated aerobic coupling reaction enables direct amidation of heterocycles or aromatics having weakly acidic C-H bonds with a variety of nitrogen nucleophiles. These reactions provide efficient access to many biologically important skeletons, including ones with the potential to serve as inhibitors of HMTs.

SUBMITTER: Wang Q 

PROVIDER: S-EPMC2776381 | biostudies-literature | 2009 Nov

REPOSITORIES: biostudies-literature