A bridge to transcription by RNA polymerase.

ABSTRACT: A comprehensive survey of single amino-acid substitution mutations critical for RNA polymerase function published in Journal of Biology supports a proposed mechanism for polymerase action in which movement of the polymerase 'bridge helix' promotes transcriptional activity in cooperation with a critical substrate-interaction domain, the 'trigger loop'.

SUBMITTER: Kaplan CD 

PROVIDER: S-EPMC2776398 | biostudies-literature | 2008 Dec

REPOSITORIES: biostudies-literature