Condition-adapted stress and longevity gene regulation by Caenorhabditis elegans SKN-1/Nrf.

ABSTRACT: Studies in model organisms have identified regulatory processes that profoundly influence aging, many of which modulate resistance against environmental or metabolic stresses. In Caenorhabditis elegans, the transcription regulator SKN-1 is important for oxidative stress resistance and acts in multiple longevity pathways. SKN-1 is the ortholog of mammalian Nrf proteins, which induce Phase 2 detoxification genes in response to stress. Phase 2 enzymes defend against oxygen radicals and conjugate electrophiles that are produced by Phase 1 detoxification enzymes, which metabolize lipophilic compounds. Here, we have used expression profiling to identify genes and processes that are regulated by SKN-1 under normal and stress-response conditions. Under nonstressed conditions SKN-1 upregulates nume

SUBMITTER: Oliveira RP 

PROVIDER: S-EPMC2776707 | biostudies-literature | 2009 Sep

REPOSITORIES: biostudies-literature