Degradation of activated protein kinases by ubiquitination.

ABSTRACT: Protein kinases are important regulators of intracellular signal transduction pathways and play critical roles in diverse cellular functions. Once a protein kinase is activated, its activity is subsequently downregulated through a variety of mechanisms. Accumulating evidence indicates that the activation of protein kinases commonly initiates their downregulation via the ubiquitin/proteasome pathway. Failure to regulate protein kinase activity or expression levels can cause human diseases.

SUBMITTER: Lu Z 

PROVIDER: S-EPMC2776765 | biostudies-literature | 2009

REPOSITORIES: biostudies-literature