Selection for minimization of translational frameshifting errors as a factor in the evolution of codon usage.

ABSTRACT: In a wide range of genomes, it was observed that the usage of synonymous codons is biased toward specific codons and codon patterns. Factors that are implicated in the selection for codon usage include facilitation of fast and accurate translation. There are two types of translational errors: missense errors and processivity errors. There is considerable evidence in support of the hypothesis that codon usage is optimized to minimize missense errors. In contrast, little is known about the relationship between codon usage and frameshifting errors, an important form of processivity errors, which appear to occur at frequencies comparable to the frequencies of missense errors. Based on the recently proposed pause-and-slip model of frameshifting, we developed Frameshifting Robustness Score (FRS)

SUBMITTER: Huang Y 

PROVIDER: S-EPMC2777431 | biostudies-literature | 2009 Nov

REPOSITORIES: biostudies-literature