CLOCK genetic variation and metabolic syndrome risk: modulation by monounsaturated fatty acids.

ABSTRACT:

Background

Disruption of the circadian system may be causal for manifestations of the metabolic syndrome (MetS).

Objective

The objective was to study the associations of 5 CLOCK polymorphisms with MetS features by analyzing fatty acid (FA) composition from dietary and red blood cell (RBC) membrane sources.

Design

Participants (n = 1100) in the Genetics of Lipid Lowering Drugs and Diet Network (GOLDN) study were included. Dietary intake was estimated with a validated questionnaire. Anthropometric and biochemical measurements and genotypes were determined. Postprandial lipids and the FA composition of RBC membranes were analyzed.

Results

CLOCK single nucleotide polymorphisms were significantly associated with obesity and individual components of MetS. For single

SUBMITTER: Garaulet M 

PROVIDER: S-EPMC2777463 | biostudies-literature | 2009 Dec

REPOSITORIES: biostudies-literature