The FTO gene rs9939609 obesity-risk allele and loss of control over eating.

ABSTRACT:

Background

Children with rs9939609 FTO variant alleles (homozygous = AA and heterozygous = AT) are predisposed to greater adiposity than are those with 2 wild-type alleles (TT).

Objective

Because FTO is highly expressed in hypothalamic regions that are important for appetite, FTO genotype may affect energy balance by influencing eating behavior. Loss of control (LOC) eating, a behavior commonly reported by overweight youth, predicts excessive weight gain in children. However, the relation between FTO genotype and LOC eating has not been previously examined.

Design

Two-hundred eighty-nine youth aged 6-19 y were genotyped for rs9939609, underwent body-composition measurements, and were interviewed to determine the presence or absence of LOC eating. A subset (n = 190) pa

SUBMITTER: Tanofsky-Kraff M 

PROVIDER: S-EPMC2777464 | biostudies-literature | 2009 Dec

REPOSITORIES: biostudies-literature