Effect of high-normal compared with low-normal arterial pH on protein balances in automated peritoneal dialysis patients.

ABSTRACT:

Background

Although the protein catabolic effects of metabolic acidosis are well established, it is unclear whether the entire reference range of arterial pH (7.37-7.44) is equivalent for protein balance.

Objective

We undertook this study to test the hypothesis that in patients undergoing automated peritoneal dialysis, an arterial pH of 7.43-7.45, as compared with a pH of 7.36-7.38, is associated with more-positive nitrogen balances.

Design

Eight stable subjects (5 men) aged 43.1 +/- 15.3 y completed a randomized, crossover nitrogen balance study for >or=42 d. Arterial pH was varied by changing the daily doses of sodium citrate/citric acid and ammonium chloride.

Results

The subjects attained mean (+/-SD) arterial pH values of 7.37 +/- 0.01 and 7.44 +/- 0.02 dur

SUBMITTER: Mehrotra R 

PROVIDER: S-EPMC2777467 | biostudies-literature | 2009 Dec

REPOSITORIES: biostudies-literature