A randomized trial on folic acid supplementation and risk of recurrent colorectal adenoma.

ABSTRACT:

Background

Evidence from observational studies suggests that inadequate folate status enhances colorectal carcinogenesis, but results from some randomized trials do not support this hypothesis.

Objective

To assess the effect of folic acid supplementation on recurrent colorectal adenoma, we conducted a cost-efficient, double-blind, randomized trial among participants of 2 large prospective cohorts, the Health Professionals Follow-Up Study and the Nurses' Health Study.

Design

Participants were randomly assigned to receive folic acid (1 mg/d) (n = 338) or placebo (n = 334) for 3-6.5 y. The primary endpoint was any new diagnosis of adenoma during the study period (May 1996-March 2004). Secondary outcomes were adenoma by site and stage and number of recurrent adenomas. Ass

SUBMITTER: Wu K 

PROVIDER: S-EPMC2777472 | biostudies-literature | 2009 Dec

REPOSITORIES: biostudies-literature