Recombinant squalene synthase. synthesis of cyclopentyl non-head-to-tail triterpenes.

ABSTRACT: Incubation of farnesyl diphosphate with recombinant yeast squalene synthase in the absence of NADPH gives a mixture of triterpene hydrocarbons and alcohols, including botryococcene-like compounds with 1'-3 linkages between the farnesyl units. One of these molecules has an unusual cyclopentane structure similar to those recently reported in plant extracts and lakebed sediments.

SUBMITTER: Pan JJ 

PROVIDER: S-EPMC2777528 | biostudies-literature | 2009 Oct

REPOSITORIES: biostudies-literature