Microfabricated electrospun collagen membranes for 3-D cancer models and drug screening applications.

ABSTRACT: Invasive epithelial tumors form from cells that are released from their natural basement membrane and form 3-D structures that interact with each other and with the microenvironment of the stromal tissues around the tumor, which often contains collagen. Cancer cells, growing as monolayers on tissue culture plastic, do not reflect many of the properties of whole tumors. This shortcoming limits their ability to serve as models for testing of pharmacologically active compounds, including those that are being tested as antineoplastics. This work seeks to create new 3-D cellular materials possessing properties similar to those in native tissues surrounding cancers, specifically electrospun micro- and nanofibrous collagen scaffolds that support tumor growth in 3-D. We hypothesize that a 3-D cult

SUBMITTER: Hartman O 

PROVIDER: S-EPMC2777622 | biostudies-literature | 2009 Aug

REPOSITORIES: biostudies-literature