Early blockade of injured primary sensory afferents reduces glial cell activation in two rat neuropathic pain models.

ABSTRACT: Satellite glial cells in the dorsal root ganglion (DRG), like the better-studied glia cells in the spinal cord, react to peripheral nerve injury or inflammation by activation, proliferation, and release of messengers that contribute importantly to pathological pain. It is not known how information about nerve injury or peripheral inflammation is conveyed to the satellite glial cells. Abnormal spontaneous activity of sensory neurons, observed in the very early phase of many pain models, is one plausible mechanism by which injured sensory neurons could activate neighboring satellite glial cells. We tested effects of locally inhibiting sensory neuron activity with sodium channel blockers on satellite glial cell activation in a rat spinal nerve ligation (SNL) model. SNL caused extensive satell

SUBMITTER: Xie W 

PROVIDER: S-EPMC2777638 | biostudies-literature | 2009 Jun

REPOSITORIES: biostudies-literature