Dissecting the expression dynamics of RNA-binding proteins in posttranscriptional regulatory networks.

ABSTRACT: In eukaryotic organisms, gene expression requires an additional level of coordination that links transcriptional and posttranslational processes. Messenger RNAs have traditionally been viewed as passive molecules in the pathway from transcription to translation. However, it is now clear that RNA-binding proteins (RBPs) play an important role in cellular homeostasis by controlling gene expression at the posttranscriptional level. Here, we show that RBPs, as a class of proteins, show distinct gene expression dynamics compared to other protein coding genes in the eukaryote Sacchoromyces cerevisiae. We find that RBPs generally exhibit high protein stability, translational efficiency, and protein abundance but their encoding transcripts tend to have a low half-life. We show that RBPs are also m

SUBMITTER: Mittal N 

PROVIDER: S-EPMC2777960 | biostudies-literature | 2009 Dec

REPOSITORIES: biostudies-literature