Correlation of RNA secondary structure statistics with thermodynamic stability and applications to folding.

ABSTRACT: The accurate prediction of the secondary and tertiary structure of an RNA with different folding algorithms is dependent on several factors, including the energy functions. However, an RNA higher-order structure cannot be predicted accurately from its sequence based on a limited set of energy parameters. The inter- and intramolecular forces between this RNA and other small molecules and macromolecules, in addition to other factors in the cell such as pH, ionic strength, and temperature, influence the complex dynamics associated with transition of a single stranded RNA to its secondary and tertiary structure. Since all of the factors that affect the formation of an RNAs 3D structure cannot be determined experimentally, statistically derived potential energy has been used in the prediction o

SUBMITTER: Wu JC 

PROVIDER: S-EPMC2778063 | biostudies-literature | 2009 Aug

REPOSITORIES: biostudies-literature