Improvement in lipid profiles over 6 years of follow-up in adults with AIDS and immune reconstitution.

ABSTRACT:

Objectives

The aim of the study was to evaluate long-term changes in lipids and to assess other coronary heart disease (CHD) risk factors in highly experienced AIDS patients with immune reconstitution, and to examine their association with antiretroviral therapy (ART).

Methods

We evaluated 433 AIDS patients with prior severe immunosuppression and ART-based immune reconstitution, followed in a multicentre prospective observational study between 2000 and 2006. We estimated the prevalence at entry of hypercholesterolaemia and metabolic syndrome, and 10-year CHD risks. Trends in total cholesterol (TC), triglycerides (TG) and high-density lipoprotein (HDL) cholesterol were evaluated over time, and use of specific ART drugs at each study visit was assessed using mixed effect model

SUBMITTER: Williams P 

PROVIDER: S-EPMC2778216 | biostudies-literature | 2009 May

REPOSITORIES: biostudies-literature