Disclosure of APOE genotype for risk of Alzheimer's disease.

ABSTRACT:

Background

The apolipoprotein E (APOE) genotype provides information on the risk of Alzheimer's disease, but the genotyping of patients and their family members has been discouraged. We examined the effect of genotype disclosure in a prospective, randomized, controlled trial.

Methods

We randomly assigned 162 asymptomatic adults who had a parent with Alzheimer's disease to receive the results of their own APOE genotyping (disclosure group) or not to receive such results (nondisclosure group). We measured symptoms of anxiety, depression, and test-related distress 6 weeks, 6 months, and 1 year after disclosure or nondisclosure.

Results

There were no significant differences between the two groups in changes in time-averaged measures of anxiety (4.5 in the disclosure group

SUBMITTER: Green RC 

PROVIDER: S-EPMC2778270 | biostudies-literature | 2009 Jul

REPOSITORIES: biostudies-literature