Synaptic proteome changes in the superior frontal gyrus and occipital cortex of the alcoholic brain.

ABSTRACT: Cognitive deficits and behavioral changes that result from chronic alcohol abuse are a consequence of neuropathological changes which alter signal transmission through the neural network. To focus on the changes that occur at the point of connection between the neural network cells, synaptosomal preparations from post-mortem human brain of six chronic alcoholics and six non-alcoholic controls were compared using 2D-DIGE. Functionally affected and spared regions (superior frontal gyrus, SFG, and occipital cortex, OC, respectively) were analyzed from both groups to further investigate the specific pathological response that alcoholism has on the brain. Forty-nine proteins were differentially regulated between the SFG of alcoholics and the SFG of controls and 94 proteins were regulated in the

SUBMITTER: Etheridge N 

PROVIDER: S-EPMC2778313 | biostudies-literature | 2009 Jun

REPOSITORIES: biostudies-literature