Genome analysis with inter-nucleotide distances.

ABSTRACT:

Motivation

DNA sequences can be represented by sequences of four symbols, but it is often useful to convert the symbols into real or complex numbers for further analysis. Several mapping schemes have been used in the past, but they seem unrelated to any intrinsic characteristic of DNA. The objective of this work was to find a mapping scheme directly related to DNA characteristics and that would be useful in discriminating between different species. Mathematical models to explore DNA correlation structures may contribute to a better knowledge of the DNA and to find a concise DNA description.

Results

We developed a methodology to process DNA sequences based on inter-nucleotide distances. Our main contribution is a method to obtain genomic signatures for complete genomes, based

SUBMITTER: Afreixo V 

PROVIDER: S-EPMC2778338 | biostudies-literature | 2009 Dec

REPOSITORIES: biostudies-literature