Hypoxia, Snail and incomplete epithelial-mesenchymal transition in breast cancer.

ABSTRACT:

Background

Hypoxia is an element of the tumour microenvironment that impacts upon numerous cellular factors linked to clinical aggressiveness in cancer. One such factor, Snail, a master regulator of the epithelial-mesenchymal transition (EMT), has been implicated in key tumour biological processes such as invasion and metastasis. In this study we set out to investigate regulation of EMT in hypoxia, and the importance of Snail in cell migration and clinical outcome in breast cancer.

Methods

Four breast cancer cell lines were exposed to 0.1% oxygen and expression of EMT markers was monitored. The migratory ability was analysed following Snail overexpression and silencing. Snail expression was assessed in 500 tumour samples from premenopausal breast cancer patients, randomised

SUBMITTER: Lundgren K 

PROVIDER: S-EPMC2778529 | biostudies-literature | 2009 Nov

REPOSITORIES: biostudies-literature