Abnormal expression of TRIB3 in colorectal cancer: a novel marker for prognosis.

ABSTRACT:

Background

TRIB3 is a human homologue of Drosophila tribbles. Previous studies have shown that TRIB3 controls the cell growth through ubiquitination-dependent degradation of other proteins, whereas its significance in the prognosis of colorectal cancer (CRC) is not yet fully understood.

Materials

This study comprised 202 patients who underwent surgery for CRC, as well as 22 cell lines derived from human gastrointestinal cancer. The correlation of gene expression with clinical parameters in patients was assessed. The biological significance was evaluated by knockdown experiments in seven colorectal cancer cell lines.

Results

A total of 20 cancer cell lines (90.9%) expressed the TRIB3 gene. The assessment in surgical specimens indicated that the gene expression was sign

SUBMITTER: Miyoshi N 

PROVIDER: S-EPMC2778541 | biostudies-literature | 2009 Nov

REPOSITORIES: biostudies-literature