Expression of an IKKgamma splice variant determines IRF3 and canonical NF-kappaB pathway utilization in ssRNA virus infection.

ABSTRACT:

Unlabelled

Single stranded RNA (ssRNA) virus infection activates the retinoic acid inducible gene I (RIG-I)- mitochondrial antiviral signaling (MAVS) complex, a complex that coordinates the host innate immune response via the NF-kappaB and IRF3 pathways. Recent work has shown that the IkappaB kinase (IKK)gamma scaffolding protein is the final common adapter protein required by RIG-I.MAVS to activate divergent rate-limiting kinases downstream controlling the NF-kappaB and IRF3 pathways. Previously we discovered a ubiquitous IKKgamma splice-variant, IKKgammaDelta, that exhibits distinct signaling properties.

Methodology/principal findings

We examined the regulation and function of IKKgamma splice forms in response to ssRNA virus infection, a condition that preferentially induc

SUBMITTER: Liu P 

PROVIDER: S-EPMC2778955 | biostudies-literature | 2009 Nov

REPOSITORIES: biostudies-literature