Common effects of lithium and valproate on mitochondrial functions: protection against methamphetamine-induced mitochondrial damage.

ABSTRACT: Accumulating evidence suggests that mitochondrial dysfunction plays a critical role in the progression of a variety of neurodegenerative and psychiatric disorders. Thus, enhancing mitochondrial function could potentially help ameliorate the impairments of neural plasticity and cellular resilience associated with a variety of neuropsychiatric disorders. A series of studies was undertaken to investigate the effects of mood stabilizers on mitochondrial function, and against mitochondrially mediated neurotoxicity. We found that long-term treatment with lithium and valproate (VPA) enhanced cell respiration rate. Furthermore, chronic treatment with lithium or VPA enhanced mitochondrial function as determined by mitochondrial membrane potential, and mitochondrial oxidation in SH-SY5Y cells. In-vi

SUBMITTER: Bachmann RF 

PROVIDER: S-EPMC2779114 | biostudies-literature | 2009 Jul

REPOSITORIES: biostudies-literature