Ontology highlight
ABSTRACT:
SUBMITTER: Cross BC
PROVIDER: S-EPMC2779136 | biostudies-literature | 2009 Dec
REPOSITORIES: biostudies-literature
Journal of cell science 20091110 Pt 23
Production and trafficking of proteins entering the secretory pathway of eukaryotic cells is coordinated at the endoplasmic reticulum (ER) in a process that begins with protein translocation via the membrane-embedded ER translocon. The same complex is also responsible for the co-translational integration of membrane proteins and orchestrates polypeptide modifications that are often essential for protein function. We now show that the previously identified inhibitor of ER-associated degradation ( ...[more]