Eradication of Helicobacter pylori in functional dyspepsia: randomised double blind placebo controlled trial with 12 months' follow up. The Optimal Regimen Cures Helicobacter Induced Dyspepsia (ORCHID) Study Group.

ABSTRACT:

Objectives

To determine whether eradication of Helicobacter pylori relieves the symptoms of functional dyspepsia.

Design

Multicentre randomised double blind placebo controlled trial.

Subjects

278 patients infected with H pylori who had functional dyspepsia.

Setting

Predominantly secondary care centres in Australia, New Zealand, and Europe.

Intervention

Patients randomised to receive omeprazole 20 mg twice daily, amoxicillin 1000 mg twice daily, and clarithromycin 500 mg twice daily or placebo for 7 days. Patients were followed up for 12 months.

Main outcome measures

Symptom status (assessed by diary cards) and presence of H pylori (assessed by gastric biopsies and 13C-urea breath testing using urea labelled with carbon-13).

Results

H pylori

SUBMITTER: Talley NJ 

PROVIDER: S-EPMC27795 | biostudies-literature | 1999 Mar

REPOSITORIES: biostudies-literature