Network properties of complex human disease genes identified through genome-wide association studies.

ABSTRACT:

Background

Previous studies of network properties of human disease genes have mainly focused on monogenic diseases or cancers and have suffered from discovery bias. Here we investigated the network properties of complex disease genes identified by genome-wide association studies (GWAs), thereby eliminating discovery bias.

Principal findings

We derived a network of complex diseases (n = 54) and complex disease genes (n = 349) to explore the shared genetic architecture of complex diseases. We evaluated the centrality measures of complex disease genes in comparison with essential and monogenic disease genes in the human interactome. The complex disease network showed that diseases belonging to the same disease class do not always share common disease genes. A possible explanati

SUBMITTER: Barrenas F 

PROVIDER: S-EPMC2779513 | biostudies-literature | 2009 Nov

REPOSITORIES: biostudies-literature