Cofactor-activated phosphorylation is required for inhibition of cortical neuron differentiation by Groucho/TLE1.

ABSTRACT:

Background

Transcriptional co-repressors of the Groucho/transducin-like Enhancer of split (Gro/TLE) family regulate the expression of a variety of genes and are involved in numerous developmental processes in both invertebrate and vertebrate species. More specifically, Gro/TLE1 participates in mechanisms that inhibit/delay the differentiation of cerebral cortex neural progenitor cells into neurons during mammalian forebrain development. The anti-neurogenic function of Gro/TLE1 depends on the formation of protein complexes with specific DNA-binding transcription factors that engage Gro/TLE1 through WRP(W/Y) sequences. Interaction with those transcription partners results in Gro/TLE1 recruitment to selected DNA sites and causes increased Gro/TLE1 phosphorylation. The physiological si

SUBMITTER: Buscarlet M 

PROVIDER: S-EPMC2779591 | biostudies-literature | 2009 Dec

REPOSITORIES: biostudies-literature