Valsartan vs. other angiotensin II receptor blockers in the treatment of hypertension: a meta-analytical approach.

ABSTRACT:

Objective

To compare the efficacy of valsartan in systolic (SBP) and diastolic blood pressure (DBP) reduction with other angiotensin II receptor blockers (ARBs) in essential hypertension.

Methods

Systematic literature search of databases between October 1997 and May 2008. Meta-analysis of short-term, double-blind, parallel group, randomised controlled trials (RCTs) for treatment of adult hypertension (DBP: 90-115 mmHg). Random-effects meta-regression adjusting for baseline blood pressure (BP) was used to analyse the data. Mean change in SBP and DBP was estimated for each individual drug and dose combination.

Results

In all, 31 RCTs (n = 13,110 patients) were included in the analysis. Six studies include trial arms with candesartan, six irbesartan, 13 losartan, two olm

SUBMITTER: Nixon RM 

PROVIDER: S-EPMC2779985 | biostudies-literature | 2009 May

REPOSITORIES: biostudies-literature