Mac-1 (CD11b/CD18) links inflammation and thrombosis after glomerular injury.

ABSTRACT:

Background

Inflammation and thrombosis coexist in several disorders. Although it is recognized that leukocytes may induce a procoagulant state at sites of inflammation, the critical molecular determinants of this process remain largely unknown.

Methods and results

To examine mechanisms of inflammation-induced thrombosis, we developed a murine model of thrombotic glomerulonephritis (TGN), a known cause of acute renal failure in patients. This model, induced by lipopolysaccharide and antibody to the glomerular basement membrane, led to rapid glomerular neutrophil recruitment, thrombotic glomerular lesions with endothelial cell injury, and renal dysfunction. In mice immunodepleted of neutrophils or lacking the leukocyte-specific integrin Mac-1, neutrophil recruitment, endotheli

SUBMITTER: Hirahashi J 

PROVIDER: S-EPMC2780001 | biostudies-literature | 2009 Sep

REPOSITORIES: biostudies-literature