High-resolution mapping of meiotic crossovers and non-crossovers in yeast.

ABSTRACT: Meiotic recombination has a central role in the evolution of sexually reproducing organisms. The two recombination outcomes, crossover and non-crossover, increase genetic diversity, but have the potential to homogenize alleles by gene conversion. Whereas crossover rates vary considerably across the genome, non-crossovers and gene conversions have only been identified in a handful of loci. To examine recombination genome wide and at high spatial resolution, we generated maps of crossovers, crossover-associated gene conversion and non-crossover gene conversion using dense genetic marker data collected from all four products of fifty-six yeast (Saccharomyces cerevisiae) meioses. Our maps reveal differences in the distributions of crossovers and non-crossovers, showing more regions where eithe

SUBMITTER: Mancera E 

PROVIDER: S-EPMC2780006 | biostudies-literature | 2008 Jul

REPOSITORIES: biostudies-literature