A major genetic locus in Trypanosoma brucei is a determinant of host pathology.

ABSTRACT: The progression and variation of pathology during infections can be due to components from both host or pathogen, and/or the interaction between them. The influence of host genetic variation on disease pathology during infections with trypanosomes has been well studied in recent years, but the role of parasite genetic variation has not been extensively studied. We have shown that there is parasite strain-specific variation in the level of splenomegaly and hepatomegaly in infected mice and used a forward genetic approach to identify the parasite loci that determine this variation. This approach allowed us to dissect and identify the parasite loci that determine the complex phenotypes induced by infection. Using the available trypanosome genetic map, a major quantitative trait locus (QTL) wa

SUBMITTER: Morrison LJ 

PROVIDER: S-EPMC2780326 | biostudies-literature | 2009 Dec

REPOSITORIES: biostudies-literature