A theoretical approach to spot active regions in antimicrobial proteins.

ABSTRACT:

Background

Much effort goes into identifying new antimicrobial compounds able to evade the increasing resistance of microorganisms to antibiotics. One strategy relies on antimicrobial peptides, either derived from fragments released by proteolytic cleavage of proteins or designed from known antimicrobial protein regions.

Results

To identify these antimicrobial determinants, we developed a theoretical approach that predicts antimicrobial proteins from their amino acid sequence in addition to determining their antimicrobial regions. A bactericidal propensity index has been calculated for each amino acid, using the experimental data reported from a high-throughput screening assay as reference. Scanning profiles were performed for protein sequences and potentially active stretch

SUBMITTER: Torrent M 

PROVIDER: S-EPMC2780422 | biostudies-literature | 2009 Nov

REPOSITORIES: biostudies-literature