SnoRNAs from the filamentous fungus Neurospora crassa: structural, functional and evolutionary insights.

ABSTRACT:

Background

SnoRNAs represent an excellent model for studying the structural and functional evolution of small non-coding RNAs involved in the post-transcriptional modification machinery for rRNAs and snRNAs in eukaryotic cells. Identification of snoRNAs from Neurospora crassa, an important model organism playing key roles in the development of modern genetics, biochemistry and molecular biology will provide insights into the evolution of snoRNA genes in the fungus kingdom.

Results

Fifty five box C/D snoRNAs were identified and predicted to guide 71 2'-O-methylated sites including four sites on snRNAs and three sites on tRNAs. Additionally, twenty box H/ACA snoRNAs, which potentially guide 17 pseudouridylations on rRNAs, were also identified. Although not exhaustive, the stud

SUBMITTER: Liu N 

PROVIDER: S-EPMC2780460 | biostudies-literature | 2009 Nov

REPOSITORIES: biostudies-literature