Distinct roles for ROCK1 and ROCK2 in the regulation of keratinocyte differentiation.

ABSTRACT:

Background

The human epidermis is comprised of several layers of specialized epithelial cells called keratinocytes. Normal homoeostasis of the epidermis requires that the balance between keratinocyte proliferation and terminal differentiation be tightly regulated. The mammalian serine/threonine kinases (ROCK1 and ROCK2) are well-characterised downstream effectors of the small GTPase RhoA. We have previously demonstrated that the RhoA/ROCK signalling pathway plays an important role in regulation of human keratinocyte proliferation and terminal differentiation. In this paper we addressed the question of which ROCK isoform was involved in regulation of keratinocyte differentiation.

Methodology and principal findings

We used RNAi to specifically knockdown ROCK1 or ROCK2 expressi

SUBMITTER: Lock FE 

PROVIDER: S-EPMC2780731 | biostudies-literature | 2009 Dec

REPOSITORIES: biostudies-literature