Oscillatory recruitment of signaling proteins to cell tips promotes coordinated behavior during cell fusion.

ABSTRACT: Cell-cell communication is essential for coordinating physiological responses in multicellular organisms and is required for various developmental processes, including cell migration, differentiation, and fusion. To facilitate communication, functional differences are usually required between interacting cells, which can be established either genetically or developmentally. However, genetically identical cells in the same developmental state are also capable of communicating, but must avoid self-stimulation. We hypothesized that such cells must alternate their physiological state between signal sending and receiving to allow recognition and behavioral changes. To test this hypothesis, we studied cell communication in the filamentous fungus Neurospora crassa, a simple and experimentally ame

SUBMITTER: Fleissner A 

PROVIDER: S-EPMC2780775 | biostudies-literature | 2009 Nov

REPOSITORIES: biostudies-literature